13 Comparison Report: COL/COADREAD
- Cancer Category: carcinomas
- Chip hu35ksuba: 1129 filtered probes
- Chip hu6800: 286 filtered probes
Overall Complexity & Entropy Assessment
| Measure | All Filtered Probes | GO MF Terms | KEGG Pathways | HALLMARK Genes |
|---|---|---|---|---|
| Complexity | strong loss (well supported) | () | strong loss (uncertain) | strong loss (uncertain) |
| Shannon Entropy | no clear change (moderately supported) | () | no clear change (well supported) | no clear change (uncertain) |
| Spectral Entropy | no clear change (moderately supported) | () | no clear change (moderately supported) | no clear change (uncertain) |
Notes - Gain = increased complexity from normal to tumor
- Loss = complexity reduction from normal to tumor
- Chaotic = increased entropy from normal to tumor
- Anti-Chaotic = entropy reduction from normal to tumor
- All p-values unadjusted unless noted
Gain Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 1 | 3 | 0.027 | negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
Loss Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 5 | 1 | 0.000 | protein transport |
| 9 | 2 | 0.551 | positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
⚠️ Table not available.
Significant GO Molecular Function Terms (Complexity)
Gained Complexity
| GeneSet | p-value |
|---|---|
| regulation of transcription by RNA polymerase II | 0.028 |
Lost Complexity
| GeneSet | p-value |
|---|---|
| negative regulation of transcription by RNA polymerase II | 0.041 |
| protein binding | 0.009 |
| protein transport | 0.000 |
| zinc ion binding | 0.030 |
Significant GO Molecular Function Terms (Spectral Entropy)
Mildly Anti-Chaotic
| GeneSet | p-value |
|---|---|
| zinc ion binding | 0.047 |
Neutral
| GeneSet | p-value |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | 0.001 |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | 0.008 |
Mildly Chaotic
| GeneSet | p-value |
|---|---|
| cell differentiation | 0.031 |
| negative regulation of cell population proliferation | 0.000 |
Significant KEGG Pathways (Complexity)
⚠️ Plot not available.No significant KEGG pathways found (complexity).
Significant KEGG Pathways (Spectral Entropy)
Neutral
| GeneSet | p-value | Cancer Pathway |
|---|---|---|
| Vascular smooth muscle contraction | 0.033 |
Significant HALLMARK Genes (Complexity)
No significant MSigDB gene sets found.
Significant HALLMARK Genes (Spectral Entropy)
No significant MSigDB gene sets found (spectral entropy).