18 Comparison Report: UT/EAC
- Cancer Category: carcinomas
- Chip hu35ksuba: 386 filtered probes
- Chip hu6800: 81 filtered probes
Overall Complexity & Entropy Assessment
| Measure | All Filtered Probes | GO MF Terms | KEGG Pathways | HALLMARK Genes |
|---|---|---|---|---|
| Complexity | strong gain (uncertain) | () | strong loss (uncertain) | strong gain (uncertain) |
| Shannon Entropy | no clear change (uncertain) | () | no clear change (uncertain) | no clear change (uncertain) |
| Spectral Entropy | no clear change (uncertain) | () | no clear change (uncertain) | no clear change (uncertain) |
Notes - Gain = increased complexity from normal to tumor
- Loss = complexity reduction from normal to tumor
- Chaotic = increased entropy from normal to tumor
- Anti-Chaotic = entropy reduction from normal to tumor
- All p-values unadjusted unless noted
Gain Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 6 | 1 | 0.021 | nervous system development |
| 11 | 1 | 0.045 | positive regulation of apoptotic process |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
Loss Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 13 | 3 | 0.859 | positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated |
| 1 | 3 | 0.861 | negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
⚠️ Table not available.
Significant GO Molecular Function Terms (Complexity)
Gained Complexity
| GeneSet | p-value |
|---|---|
| nervous system development | 0.021 |
| positive regulation of apoptotic process | 0.045 |
Significant GO Molecular Function Terms (Spectral Entropy)
Strongly Anti-Chaotic
| GeneSet | p-value |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | 0.000 |
| negative regulation of cell population proliferation | 0.014 |
| negative regulation of transcription by RNA polymerase II | 0.003 |
| positive regulation of apoptotic process | 0.026 |
| positive regulation of transcription, DNA-templated | 0.015 |
Significant KEGG Pathways (Complexity)
⚠️ Plot not available.No significant KEGG pathways found (complexity).
Significant KEGG Pathways (Spectral Entropy)
⚠️ Plot not available.No significant KEGG pathways found (spectral entropy).
Significant HALLMARK Genes (Complexity)
No significant MSigDB gene sets found.
Significant HALLMARK Genes (Spectral Entropy)
No significant MSigDB gene sets found (spectral entropy).