16 Comparison Report: OV/OVAD
- Cancer Category: carcinomas
- Chip hu35ksuba: 180 filtered probes
- Chip hu6800: 181 filtered probes
Overall Complexity & Entropy Assessment
| Measure | All Filtered Probes | GO MF Terms | KEGG Pathways | HALLMARK Genes |
|---|---|---|---|---|
| Complexity | strong gain (well supported) | () | strong gain (uncertain) | strong gain (well supported) |
| Shannon Entropy | no clear change (uncertain) | () | no clear change (uncertain) | no clear change (uncertain) |
| Spectral Entropy | no clear change (uncertain) | () | no clear change (uncertain) | no clear change (uncertain) |
Notes - Gain = increased complexity from normal to tumor
- Loss = complexity reduction from normal to tumor
- Chaotic = increased entropy from normal to tumor
- Anti-Chaotic = entropy reduction from normal to tumor
- All p-values unadjusted unless noted
Gain Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 20 | 1 | 0.043 | actin filament organization |
| 11 | 2 | 0.539 | positive regulation of cell migration; positive regulation of cell migration |
| 10 | 3 | 0.849 | cell differentiation; cell differentiation; fat cell differentiation |
| 8 | 2 | 0.948 | positive regulation of gene expression; positive regulation of gene expression |
| 2 | 7 | 0.950 | regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
Loss Complexity Clusters
| Cluster | # Terms | p-value | Representative Terms |
|---|---|---|---|
| 1 | 4 | 0.574 | negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II |
| 4 | 2 | 0.623 | apoptotic process; apoptotic process |
| * Combined p-values are computed using Fisher’s method (sumlog) across the GO terms in each cluster. |
⚠️ Table not available.
Significant GO Molecular Function Terms (Complexity)
Gained Complexity
| GeneSet | p-value |
|---|---|
| RNA binding | 0.039 |
| actin filament organization | 0.043 |
| zinc ion binding | 0.035 |
Significant GO Molecular Function Terms (Spectral Entropy)
Mildly Anti-Chaotic
| GeneSet | p-value |
|---|---|
| fat cell differentiation | 0.034 |
| positive regulation of transcription, DNA-templated | 0.035 |
Significant KEGG Pathways (Complexity)
⚠️ Plot not available.No significant KEGG pathways found (complexity).
Significant KEGG Pathways (Spectral Entropy)
⚠️ Plot not available.No significant KEGG pathways found (spectral entropy).
Significant HALLMARK Genes (Complexity)
Gained Complexity
| GeneSet | p-value |
|---|---|
| HALLMARK_APOPTOSIS | 0.028 |
Significant HALLMARK Genes (Spectral Entropy)
Neutral
| GeneSet | p-value |
|---|---|
| HALLMARK_UV_RESPONSE_DN | 0.044 |